A jack of all trades, so to speak, Leonardo da Vinci towers over Renaissance art, sculpture, invention, and science. But let's focus on his artistic ouvres (works) for now.
The Mona Lisa: I heard somewhere that the original model, the Lady of Gioconda, had no eyebrows. Is she smiling, or grimacing? What the heck is that landscape behind her?
Mona Lisa Happy by Tito.
The Last Supper: It's a little hard to believe that Jesus and the disciples all sat on one side of the table, but oh well. Plus, being of that era, they would've been reclining, not sitting in chairs. The dude next to Jesus on the left, supposedly John, looks like a sissy-girl. (Mary Magdelene?)
You gotta give da Vinci some credit, though. He sure knew his stuff about how to draw people well. Like his Madonnas. If "Saint" Mary looked like that, I would've gone out with her. Maybe.